Dipeptide dertivative Fmoc-10a belong to aurantiamide derivatives, which composed of phenylalaninol and phenylalanine. Aurantiamides exhibited anti-bacterial, anti-inflammatory, antioxidant, anti-HIV and anti-cancer effects. In this invention, the inventors reveal that Fmoc-10a exhibits novel anti-angiogenic activity, and provide the application of aurantiamide dipeptide Fmco-10a and its medicine regiment for inhibition of pathological neovascularization in the treatment of angiogenesis-related disease, such as cancer and age-related Macular Degeneration.
Features / strengths
The novel chemical skeleton to impede pathological neovascularization.
Specification in detail