Introduction
Human liver chimeric mice (HepMice) is a mouse model with resident human hepatocytes within mice liver organ . This mice are designed by engrafting human adult hepatocytes from certified donors into immunodeficient FAH knock-out mice (Fah–/– NOD-SCID-IL2rg–/–). Repetitive cycles of liver injury and repair eventually leads to replacement of mouse hepatocytes with human hepatocytes. High level of human hepatocytes repopulations were reported in the liver of HepMice. This model has huge potential in drug metabolism studies and efficacy studies for fatty liver, Hepatitis viral infection, malaria and for hepatotoxicity studies.
Features / strengths
•>90% Purity of Human Hepatocytes
•>1mg/ml of Human Albumin
•Liver functions – Phase I Cytochrome P450 Metabolism
•Disease Modelling
Specification in detail
Supporting document
