Introduction
Invivocue’s proprietary HiMice are a humanised mouse model with a stably reconstituted human immune system. HiMice are designed by engrafting human CD34+ hematopoietic stem cells derived from human cord blood into immunodeficient mice. Our HiMice stably express multiple human cell lineages in the blood circulation and organs, including the spleen, thymus, bone marrow, liver, lung and intestine.
Features / strengths
•Reconstitution Levels: Blood recon > 20% | Organ recon > 80%
•Functional cell lineages: CD3+, CD4+, CD8+, T cells, B cells and NK cells
•Stably engrafted for more than a year without GvHD
•Suitable for long term studies
•Display T-cell dependent inflammatory response and T-maturation in spleen
•Can produce over 100 mice from a single cord blood donor
•Complimentary HLA Matching and Gender Selection
•Flexible and can be further modified through cytokine injections
Specification in detail
Supporting document
