We propose a low-cost, portable nanostructure-based surface plasmon resonance imaging (SPRi) platform, composed of a commercial transmission scanner, nanostructure-based biochips, and self-referencing two-color analysis, for high-throughput sensing applications, such as kinetic studies of living cell activities, screening anti-metastasis drugs, kinetic studies of biomolecular interactions, and direct detection of SARS-CoV-2 virus-like particles. Such a portable, low-cost, and high-throughput sensing platform can benefit various multiplex sensing applications.

According to the global label-free detection market report, surface plasmon resonance is one of the significant innovations utilized in label free detection. This is seen as a lucrative opportunity for the growth of market in the next few years. However, high cost of instruments as well as issues in sensitivity and throughput will also act as a restraint to the market. We propose metallic nanostructure-based surface plasmon resonance imaging platforms with a high cost-performance ratio to address those issues. Compared to competitive products on the market, our sensing platforms have a higher cost-performance ratio and could be sold at an affordable price for bio laboratories, which can benefit the promotion and various applications of this technology.