Introduction
Nucleic Acid Production
-Scale-up from tube to 250 mL bioreactor
-Production yield is about 7 mg/ml
(DNA:mRNA=1:130 by weight ratio)
LNP Delivery System
-Easy scale-up of LNP formulations developed on the microfluidic technology
-Formulation of 1.0 mL to 1 L batches
-Develop protocols to validate scale-up
Features / strengths
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases, the Lipid nanoparticles (LNPs) are chosen as a carrier vehicle to protect the mRNA from degradation and aid intracellular delivery and endosomal escape. In vitro transcription (IVT) is the method of choice to produce long and stable RNA molecules, our IVT mRNA synthesis system offers a complete solution for synthesizing high-quality single-stranded mRNA from gene of interest, with a cap structure and poly(A) sequence.
Specification in detail
mRNA-LNP Development
There is no mRNA-LNP product, only the manufacturing process.
