Introduction
nterleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Features / strengths
Source:
Escherichia coli
Animal-free reagent and laboratory
Manufactured and tested under GMP guideline
Endotoxin level:
<0.01 EU per 1 μg of the protein by the LAL method.
Activity:
Measure by its ability to induce proliferation in CTLL-2 cells. The ED50 for this effect is <0.2 ng/mL.
The specific activity of recombinant human IL-2 is approximately >2.5 x 107 IU/mg.
Measure by its ability to induce proliferation in NK cells. The ED50 for this effect is <46 ng/mL.
Purity:
>98% as determined by SDS-PAGE analysis. Purified by Ni-NTA chromatography.
Specification in detail
