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Bio B2BSofiva Genomics 〉Applying next generation sequencing in preimplantation genetic screening

Applying next generation sequencing in preimplantation genetic screening

Applying next generation sequencing in preimplantation genetic screening

1. The detection rate is 99.9%.2. Its specificity and sensitivity are high.3. Leads to greater implantation rates and improved IVF outcomes.4. Enables single embryo transfers with higher chance of success.

Request for Collaboration
Overview
In the past, preimplantation genetic screening with fluorescent in situ hybridization (FISH) has been used to select normal or balanced embryos for transfer. However, FISH has some drawbacks including difficulties cell fixation, signal reading and only allow identification for a limited number of chromosome. In contrast, array-comparative genomic hybridization (aCGH) can detect translocation and 24 chromosomes that has become an established alternative to FISH for PGS of aneuploidies, unbalanced translocations and complex karyotypes with multiple rearrangements. Next generation sequencing is a rapidly developing and promising technique for gene and chromosomal examinations. Chromosomal copy number calculation based on NGS offer several benefits to array-CGH including: (1) cost of PGS could be reduced; (2) sample number increased simultaneously sequenced in a single experiment; (3) resolution could be improved for detection of few megabases; (4) experimental procedures simplified that could minimize operated errors, diminish hands-on time, and empower higher throughput and consistency. Recently investigator explored whether NGS could be reliably applied for PGS, by performing an extensive preclinical validation of a NGS-based 24-chromosome aneuploidy screening protocol. The study demonstrated that NGS is robust methodology that may find a place in routine clinical application.
Application
1. Who is advanced maternal age (34 or above).
2. Who has repeated pregnancy loss.
3. Who has repeated implantation failure.
4. Who has a family history of chromosomal abnormalities.
5. Who wants to avoid chromosomal aneuploidies.
More Information
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